Certain Dri Prescription Strength Clinical Roll-On

4.23/5 - 197 reviews

Most effective antiperspirant you can buy without a prescription

Certain Dri Prescription Strength Roll-On is prescription strength, with 12% Aluminum Chloride, and the most effective antiperspirant you can buy without a prescription. Other antiperspirants may have aluminum complexes at higher percentages – but they are not the same. Aluminum Chloride is the strongest and most effective active ingredient available in antiperspirants and is the same active ingredient in many prescription formulations. Aluminum Chloride is the #1 doctor recommended active ingredient for excessive sweating** and is why Certain Dri Prescription Strength Roll-On is different from the rest.

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Who is Certain Dri Prescription Strength Clinical Roll-On for? Anyone suffering from hyperhidrosis or excessive sweating looking for the strongest protection available without a prescription.


  • Apply Certain Dri antiperspirant to underarms at bedtime. That’s because the active ingredient works best while you sleep to stop perspiration all day. It will not wash off the next day, even after bathing or showering.
  • Apply sparingly to completely dry armpit. Apply Certain Dri sparingly – only a few strokes under each arm. To reduce the risk of irritation, be sure underarms are completely dry before applying.
  • For added deodorant protection, Certain Dri Everyday Strength Clinical antiperspirant + deodorant may also be reapplied in the morning for an extra layer of freshness and protection.

*Based on a 2017 independent study, Certain Dri is the #1 doctor recommended brand for excessive sweating.
**Based on a 2017 independent study, Aluminum Chloride is #1 doctor recommended ingredient for excessive sweating.

More about Aluminum Chloride

Certain Dri Prescription Strength Clinical Roll-On is unique in that it contains the strongest, most effective active ingredient – aluminum chloride, the #1 doctor recommended ingredient. This is also the active ingredient that is found in many prescription antiperspirants. This Certain Dri formulation is water-based instead of alcohol-based, so it’s gentler on your skin than prescription antiperspirants.

Aluminum chloride works differently than other aluminum compounds. It penetrates to a deeper level of the sweat gland to stop sweat where it starts. Aluminum chloride molecules are smaller and fill the sweat duct more effectively than larger aluminum compounds. This means that the active ingredient in Certain Dri Prescription Strength Clinical Roll-On will help prevent perspiration more effectively, and won’t wash off in the shower.

aluminum chloride

The pink circles above represent the molecules in other clinical antiperspirants as they enter a sweat gland in your underarm.

sweat gland

Most clinical OTC (over-the-counter) antiperspirant brands use Aluminum Zirconium Complex (15-20%) as their active ingredient. This antiperspirant ingredient contains larger molecules that sweat “grabs” and pulls them into the sweat duct to form a plug.

aluminum in deodorant

Certain Dri® Prescription Strength Clinical Roll-On, represented by the green circles, stops sweat on a deeper level by using Aluminum Chloride, an ingredient with smaller molecules, which is more effective in getting into the pore and reducing sweat on a deeper level.

If you’re looking for real “clinical strength” antiperspirant options that can help you with excessive underarm sweating, try Certain Dri®, the #1 doctor recommended brand.

Aluminum Chloride – smallest molecule support

  • AlCl₃ is a simple inorganic salt compound, while aluminum chlorohydrate and other antiperspirant actives are best described as inorganic polymers that form relatively large poly-aluminum complexes based on repeating Al-13 units.
  • Size exclusion chromatography, such as HPLC, separates and characterizes materials on the basis of molecular size. With this techniques, the larger molecules pass through the column faster, while the smaller molecules come out slower. Tests clearly illustrate that AlCl₃ is smaller.
  • By using the molecular formula for AlCl3, and the empirical formulas for ACH of Al₂(OH)₅Cl and a typical AZG-tetra salt of ZrAl₂Cl₃.₃₁(OH)₆.₆₉, the molecular weights can be computed as 133.34, 174.45, and 370.59 gm/mole respectively.
  • Aluminum chloride is the smallest molecule based on basic chemistry considerations, being applied to antiperspirant actives.

Certain Dri – A certified cruelty free product by PETA

Certain Dri® products are not animal tested and are certified cruelty free by PETA (People for the Ethical Treatment of Animals). PETA is the largest animal rights organization in the world, with more than 3 million members and supporters. To learn more about PETA, and companies that do not test on animals, visit www.peta.org.

Reviews (197)


May 31, 2018

Best solution ever
Been a user years ago. This product saved my social life. I use it once a month and ready to go out there!

Rajiv shrestha

May 24, 2018

It won't work
I bought this product a week ago.i used this after shower before go to bed..it doesn't itiching or even anything..next day at morning time it's work.but at afternoon it won't.plz advice me what should i do now? I apply only once times..thankyou


May 7, 2018

Very Good
I have hyperhidrosis and haven't been using this product for very long but so far it has been working really well. It does sting after application for a bit but other than that I don't have any complaints. I also use a thin layer of my dove deodorant to keep me smelling fresh.


Apr 27, 2018

The best antiperspirant
Certain Dri does a great job. The only downside is that it stings for a while after you put it on, though I haven't noticed any lasting irritation. Read the instructions carefully and don't use very much. 3 swipes MAX.

You also need to wear a separate deodorant with this because it doesn't eliminate odours, just excessive wetness.


Apr 27, 2018

no sweat, but irritation is unbearable
I've only used this product for the past three days now and I am a 16 year old sophomore girl who has had sweating problems throughout middle school until now. I could only wear dark sweaters to school and black shirts to sports due to the problem. I tried this product and my sweat went completely away, even during sports! It's great, but I am consistantly losing sleep after I put this product on. The irritation is so incredibly unbearable that I truly believe I'd rather sweat. I'm typing this review at midnight because the irritation and rashing is so awful. I recommend this product, but I've followed every step on the website and box and the uncomfort is ridiculous. Don't think I can apply this product anymore due to the severe discomfort. It feels like a 3rd degree sunburn under my armpits, even after it's dried. It's up to you to decide if losing sleep is worth a day with no sweat.
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