Certain Dri Prescription Strength Clinical Roll-On

4.25/5 - 191 review

Most effective antiperspirant you can buy without a prescription

Certain Dri Prescription Strength Roll-On is prescription strength, with 12% Aluminum Chloride, and the most effective antiperspirant you can buy without a prescription. Other antiperspirants may have aluminum complexes at higher percentages – but they are not the same. Aluminum Chloride is the strongest and most effective active ingredient available in antiperspirants and is the same active ingredient in many prescription formulations. Aluminum Chloride is the #1 doctor recommended active ingredient for excessive sweating** and is why Certain Dri Prescription Strength Roll-On is different from the rest.

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Who is Certain Dri Prescription Strength Clinical Roll-On for? Anyone suffering from hyperhidrosis or excessive sweating looking for the strongest protection available without a prescription.


  • Apply Certain Dri antiperspirant to underarms at bedtime. That’s because the active ingredient works best while you sleep to stop perspiration all day. It will not wash off the next day, even after bathing or showering.
  • Apply sparingly to completely dry armpit. Apply Certain Dri sparingly – only a few strokes under each arm. To reduce the risk of irritation, be sure underarms are completely dry before applying.
  • For added deodorant protection, Certain Dri Everyday Strength Clinical antiperspirant + deodorant may also be reapplied in the morning for an extra layer of freshness and protection.

*Based on a 2017 independent study, Certain Dri is the #1 doctor recommended brand for excessive sweating.
**Based on a 2017 independent study, Aluminum Chloride is #1 doctor recommended ingredient for excessive sweating.

More about Aluminum Chloride

Certain Dri Prescription Strength Clinical Roll-On is unique in that it contains the strongest, most effective active ingredient – aluminum chloride, the #1 doctor recommended ingredient. This is also the active ingredient that is found in many prescription antiperspirants. This Certain Dri formulation is water-based instead of alcohol-based, so it’s gentler on your skin than prescription antiperspirants.

Aluminum chloride works differently than other aluminum compounds. It penetrates to a deeper level of the sweat gland to stop sweat where it starts. Aluminum chloride molecules are smaller and fill the sweat duct more effectively than larger aluminum compounds. This means that the active ingredient in Certain Dri Prescription Strength Clinical Roll-On will help prevent perspiration more effectively, and won’t wash off in the shower.

aluminum chloride

The pink circles above represent the molecules in other clinical antiperspirants as they enter a sweat gland in your underarm.

sweat gland

Most clinical OTC (over-the-counter) antiperspirant brands use Aluminum Zirconium Complex (15-20%) as their active ingredient. This antiperspirant ingredient contains larger molecules that sweat “grabs” and pulls them into the sweat duct to form a plug.

aluminum in deodorant

Certain Dri® Prescription Strength Clinical Roll-On, represented by the green circles, stops sweat on a deeper level by using Aluminum Chloride, an ingredient with smaller molecules, which is more effective in getting into the pore and reducing sweat on a deeper level.

If you’re looking for real “clinical strength” antiperspirant options that can help you with excessive underarm sweating, try Certain Dri®, the #1 doctor recommended brand.

Aluminum Chloride – smallest molecule support

  • AlCl₃ is a simple inorganic salt compound, while aluminum chlorohydrate and other antiperspirant actives are best described as inorganic polymers that form relatively large poly-aluminum complexes based on repeating Al-13 units.
  • Size exclusion chromatography, such as HPLC, separates and characterizes materials on the basis of molecular size. With this techniques, the larger molecules pass through the column faster, while the smaller molecules come out slower. Tests clearly illustrate that AlCl₃ is smaller.
  • By using the molecular formula for AlCl3, and the empirical formulas for ACH of Al₂(OH)₅Cl and a typical AZG-tetra salt of ZrAl₂Cl₃.₃₁(OH)₆.₆₉, the molecular weights can be computed as 133.34, 174.45, and 370.59 gm/mole respectively.
  • Aluminum chloride is the smallest molecule based on basic chemistry considerations, being applied to antiperspirant actives.

Certain Dri – A certified cruelty free product by PETA

Certain Dri® products are not animal tested and are certified cruelty free by PETA (People for the Ethical Treatment of Animals). PETA is the largest animal rights organization in the world, with more than 3 million members and supporters. To learn more about PETA, and companies that do not test on animals, visit www.peta.org.

Reviews (191)


May 1, 2020

Great ,amazing !!!
This works so well it drys out your arm pits completley and if you sweat all the time it comes into play when you’re actuskky not sweating for once this is an amazing product but one fall down is that you need to apply sparingly !


Sep 2, 2019

Doesn't work since they changed it!
I have used Certan-dri for 50 years. The last year since they changed the formula it doesn't work. I could always rely on it working. Not any more. Now I am trying to figure out what else I might use or in addition to Certain-Dri. Not a happy camper.


Sep 1, 2019

Life changing
This is one of those products that I wish I had tried sooner. I would sweat (especially under emotional stress) and it was wrecking my clothes. Sometimes one underarm was dry while the other was a flood. I was wearing men’s T-shirt’s a lot more often because they are looser around the underarms. I started using certain dri and very quickly noticed a difference. Before I even completely finished the roll on my sweat was under control and I actually don’t need the product anymore. Now I recommend it to friends. I hope it helps you!


Jul 8, 2019

I am not kidding guys, this product saved my life. I used to sweat so bad I couldn't ever wear anything other than loose fitting shirts unless I wanted to wear a jacket all day along with it. I was starting to get depressed because I never felt comfortable and I always felt like I had to go to the bathroom to make sure I didn't have sweat marks. Sometimes I would feel like I would be okay only to be disappointed and have to go home early to change or end up putting my jacket on and be so uncomfortably hot and sweat even more. I almost gave up trying every single product on the shelf until I found this product online. I read the reviews and everyone using it sounded just like me and said it was the answer to their prayers. I tried it and they were so right. After about 3 days I didn't have a drop of sweat under my arms I couldn't believe it. Now 6 months later it still works wonders and I can wear whatever I want to and it doesn't even cross my mind anymore to worry about sweating. I wish I could hug all the wonderful people who made this product because they saved my life and my confidence. You can't give up until you try this! Trust me!


Jul 1, 2019

New formula doesn’t work
Devoted user of the 72 Hour formula, but recently tired out the new formula. Doesn’t work at all. What happened, Certain Dri? Bring back the old formula.
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