Certain Dri Prescription Strength Clinical Roll-On

4.18/5 - 217 reviews

Most effective antiperspirant you can buy without a prescription

Certain Dri Prescription Strength Roll-On is prescription strength, with 12% Aluminum Chloride, and the most effective antiperspirant you can buy without a prescription. Other antiperspirants may have aluminum complexes at higher percentages – but they are not the same. Aluminum Chloride is the strongest and most effective active ingredient available in antiperspirants and is the same active ingredient in many prescription formulations. Aluminum Chloride is the #1 doctor recommended active ingredient for excessive sweating** and is why Certain Dri Prescription Strength Roll-On is different from the rest.

Buy Now

Who is Certain Dri Prescription Strength Clinical Roll-On for? This prescription strength antiperspirant contains 12% Aluminum Chloride, which is the #1 doctor recommended active ingredient for combating excessive sweating. It is the most effective antiperspirant you can buy without a prescription and has been shown to last up to 72 hours.


  • Best Practice Is Before Bed

    Antiperspirants work best while you sleep to stop perspiration the next day. This is when you sweat less, allowing the active ingredient to better get into pores. Don’t worry, it will not wash off after bathing in the morning.
  • Be Certain Your Armpit Area Is Dry

    To reduce the risk of irritation, underarms must be completely dry prior to application. Do not use immediately after showering; or if skin is broken or irritated. Consider using a hair dryer on the cool setting to help dry your underarms before application.
  • Apply Certain Dri sparingly

    Only a few downward strokes under each arm are needed. Tilt bottle and roll on to cover entire underarm area. Do not use directly after shaving as this may cause irritation.
  • Pair It and Wear It

    For added deodorant protection, Certain Dri Everyday Strength Clinical Antiperspirant + Deodorant can be applied in the morning for an extra layer of freshness and protection.
Have sensitive skin? Do a patch test.

Patch testing is a method of testing a new skin care product or a new skin care ingredient to see if it will work on your unique skin. If you have sensitive or allergic skin, it's always recommended to do a patch test or consult your physician. Consider trying Certain Dri Extra Strength instead if you have sensitive skin as it contains a strong active ingredient that may be gentler on skin.

*Based on a 2017 independent study, Certain Dri is the #1 doctor recommended brand for excessive sweating.
**Based on a 2017 independent study, Aluminum Chloride is #1 doctor recommended ingredient for excessive sweating.

More about Aluminum Chloride

Certain Dri Prescription Strength Clinical Roll-On is unique in that it contains the strongest, most effective active ingredient – aluminum chloride, the #1 doctor recommended ingredient. This is also the active ingredient that is found in many prescription antiperspirants. This Certain Dri formulation is water-based instead of alcohol-based, so it’s gentler on your skin than prescription antiperspirants.

Aluminum chloride works differently than other aluminum compounds. It penetrates to a deeper level of the sweat gland to stop sweat where it starts. Aluminum chloride molecules are smaller and fill the sweat duct more effectively than larger aluminum compounds. This means that the active ingredient in Certain Dri Prescription Strength Clinical Roll-On will help prevent perspiration more effectively, and won’t wash off in the shower.

aluminum chloride

The pink circles above represent the molecules in other clinical antiperspirants as they enter a sweat gland in your underarm.

sweat gland

Most clinical OTC (over-the-counter) antiperspirant brands use Aluminum Zirconium Complex (15-20%) as their active ingredient. This antiperspirant ingredient contains larger molecules that sweat “grabs” and pulls them into the sweat duct to form a plug.

aluminum in deodorant

Certain Dri® Prescription Strength Clinical Roll-On, represented by the green circles, stops sweat on a deeper level by using Aluminum Chloride, an ingredient with smaller molecules, which is more effective in getting into the pore and reducing sweat on a deeper level.

If you’re looking for real “clinical strength” antiperspirant options that can help you with excessive underarm sweating, try Certain Dri®, the #1 doctor recommended brand.

Aluminum Chloride – smallest molecule support

  • AlCl₃ is a simple inorganic salt compound, while aluminum chlorohydrate and other antiperspirant actives are best described as inorganic polymers that form relatively large poly-aluminum complexes based on repeating Al-13 units.
  • Size exclusion chromatography, such as HPLC, separates and characterizes materials on the basis of molecular size. With this techniques, the larger molecules pass through the column faster, while the smaller molecules come out slower. Tests clearly illustrate that AlCl₃ is smaller.
  • By using the molecular formula for AlCl3, and the empirical formulas for ACH of Al₂(OH)₅Cl and a typical AZG-tetra salt of ZrAl₂Cl₃.₃₁(OH)₆.₆₉, the molecular weights can be computed as 133.34, 174.45, and 370.59 gm/mole respectively.
  • Aluminum chloride is the smallest molecule based on basic chemistry considerations, being applied to antiperspirant actives.

Certain Dri – A certified cruelty free product by PETA

Certain Dri® products are not animal tested and are certified cruelty free by PETA (People for the Ethical Treatment of Animals). PETA is the largest animal rights organization in the world, with more than 3 million members and supporters. To learn more about PETA, and companies that do not test on animals, visit www.peta.org.

Reviews (217)


Jan 8, 2019

No more excessive sweating
I’ve dealt with excessive armpit sweating since i hit puberty. A coworker told me about this product when I was in my early 20s. I decided to give it a try since I was desperate and had nothing to lose. I immediately started seeing results as my pancake sized pit stains shrunk down to coin sized stains then disappeared after a few months.

I used Certain Dri just about every day for 2 years. I ended up not being able to go to the store for a few days after my last stick ran out. After a few days I realized my pit stains hadn’t come back yet. It’s been nearly 15 years and I still don’t have to worry about excessive armpit sweating. This product changed my life personally.

I haven’t used it in years but I do remember the occasional irritation when applying it. Do the directions still warn you to wait a while after showering before applying it? (I usually waited about 30 minutes to an hour.) I didn’t see it in the directions on this site. Once I started following that warning the irritation stopped.


Jan 5, 2019

Give it time and use other products
I’ve been using Certain Dri for YEARS now. I apply at night a few times a week and when the burning and itching occur, I apply a little bit of coconut oil with a cotton ball on my underarms. If you are nervous to use coconut oil, try baby powder. Certain Dri is the only otc antipersperant i have found to work. As for smell- I’ve noticed that essential oils work best as your daily deodorant. I mix lemongrass (or any other antibacterial oil) with baking soda and just sprinkle a little on every morning. I’m telling you all- it works! Just use an oil or baby powder as a means to keep your skin from getting irritated. The essential oils mixed with baking soda will keep you smelling fresh all day too- you won’t need to buy OTC crap deodorant ever again!!


Dec 20, 2018

First Try
Im trying the product for the first time today, and when I first applied it didnt sting or ich but about 2 minuits later I started to feel ichyness where I applied, not unbarrable but noticeable.


Dec 15, 2018

My last hope
I am sensitive to medications for hyperhydrosis. The side effects are so bad that I can't take them. Certain dri was my very last hope. It burns my skin and itches REALLY bad! I still sweat as if I wasn't using it anyways. I even started wearing shorts to leave the house during winter temperatures in the Midwest and still haven't found relief. My last hope has turned into a nightmare and knowing that I am going to be stuck with my worsening condition is devastating to me. I want to runaway from my own body.


Dec 12, 2018

It Works
I have used this product twice and it has already changed my life. I don’t worry about sweating like crazy, and I feel much more comfortable and confident. I highly recommend this product - you won’t regret it
Page: 12345

Add Review