Certain Dri Prescription Strength Clinical Roll-On

4.17/5 - 214 reviews

Most effective antiperspirant you can buy without a prescription

Certain Dri Prescription Strength Roll-On is prescription strength, with 12% Aluminum Chloride, and the most effective antiperspirant you can buy without a prescription. Other antiperspirants may have aluminum complexes at higher percentages – but they are not the same. Aluminum Chloride is the strongest and most effective active ingredient available in antiperspirants and is the same active ingredient in many prescription formulations. Aluminum Chloride is the #1 doctor recommended active ingredient for excessive sweating** and is why Certain Dri Prescription Strength Roll-On is different from the rest.

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Who is Certain Dri Prescription Strength Clinical Roll-On for? Anyone suffering from hyperhidrosis or excessive sweating looking for the strongest protection available without a prescription.


  • Apply Certain Dri antiperspirant to underarms at bedtime. That’s because the active ingredient works best while you sleep to stop perspiration all day. It will not wash off the next day, even after bathing or showering.
  • Apply sparingly to completely dry armpit. Apply Certain Dri sparingly – only a few strokes under each arm. To reduce the risk of irritation, be sure underarms are completely dry before applying.
  • For added deodorant protection, Certain Dri Everyday Strength Clinical antiperspirant + deodorant may also be reapplied in the morning for an extra layer of freshness and protection.

*Based on a 2017 independent study, Certain Dri is the #1 doctor recommended brand for excessive sweating.
**Based on a 2017 independent study, Aluminum Chloride is #1 doctor recommended ingredient for excessive sweating.

More about Aluminum Chloride

Certain Dri Prescription Strength Clinical Roll-On is unique in that it contains the strongest, most effective active ingredient – aluminum chloride, the #1 doctor recommended ingredient. This is also the active ingredient that is found in many prescription antiperspirants. This Certain Dri formulation is water-based instead of alcohol-based, so it’s gentler on your skin than prescription antiperspirants.

Aluminum chloride works differently than other aluminum compounds. It penetrates to a deeper level of the sweat gland to stop sweat where it starts. Aluminum chloride molecules are smaller and fill the sweat duct more effectively than larger aluminum compounds. This means that the active ingredient in Certain Dri Prescription Strength Clinical Roll-On will help prevent perspiration more effectively, and won’t wash off in the shower.

aluminum chloride

The pink circles above represent the molecules in other clinical antiperspirants as they enter a sweat gland in your underarm.

sweat gland

Most clinical OTC (over-the-counter) antiperspirant brands use Aluminum Zirconium Complex (15-20%) as their active ingredient. This antiperspirant ingredient contains larger molecules that sweat “grabs” and pulls them into the sweat duct to form a plug.

aluminum in deodorant

Certain Dri® Prescription Strength Clinical Roll-On, represented by the green circles, stops sweat on a deeper level by using Aluminum Chloride, an ingredient with smaller molecules, which is more effective in getting into the pore and reducing sweat on a deeper level.

If you’re looking for real “clinical strength” antiperspirant options that can help you with excessive underarm sweating, try Certain Dri®, the #1 doctor recommended brand.

Aluminum Chloride – smallest molecule support

  • AlCl₃ is a simple inorganic salt compound, while aluminum chlorohydrate and other antiperspirant actives are best described as inorganic polymers that form relatively large poly-aluminum complexes based on repeating Al-13 units.
  • Size exclusion chromatography, such as HPLC, separates and characterizes materials on the basis of molecular size. With this techniques, the larger molecules pass through the column faster, while the smaller molecules come out slower. Tests clearly illustrate that AlCl₃ is smaller.
  • By using the molecular formula for AlCl3, and the empirical formulas for ACH of Al₂(OH)₅Cl and a typical AZG-tetra salt of ZrAl₂Cl₃.₃₁(OH)₆.₆₉, the molecular weights can be computed as 133.34, 174.45, and 370.59 gm/mole respectively.
  • Aluminum chloride is the smallest molecule based on basic chemistry considerations, being applied to antiperspirant actives.

Certain Dri – A certified cruelty free product by PETA

Certain Dri® products are not animal tested and are certified cruelty free by PETA (People for the Ethical Treatment of Animals). PETA is the largest animal rights organization in the world, with more than 3 million members and supporters. To learn more about PETA, and companies that do not test on animals, visit www.peta.org.

Reviews (214)


Dec 15, 2018

My last hope
I am sensitive to medications for hyperhydrosis. The side effects are so bad that I can't take them. Certain dri was my very last hope. It burns my skin and itches REALLY bad! I still sweat as if I wasn't using it anyways. I even started wearing shorts to leave the house during winter temperatures in the Midwest and still haven't found relief. My last hope has turned into a nightmare and knowing that I am going to be stuck with my worsening condition is devastating to me. I want to runaway from my own body.


Dec 12, 2018

It Works
I have used this product twice and it has already changed my life. I don’t worry about sweating like crazy, and I feel much more comfortable and confident. I highly recommend this product - you won’t regret it


Nov 22, 2018

Wear a t-shirt
This product is amazing and saved my social life. It does itch some but I find if I wear a tight T-shirt that it keeps my armpits from sticking or getting too hot and by doing that it almost eliminates the irritation completely!!! Highly recommend this product but the T-shirt trick is a must!


Oct 29, 2018

Stops sweating but itchy
This product works amazingly! I used to sweat so much no matter the weather. It could be hot or cold , no matter what i’d have a huge sweat pit under both arms by 10 in the morning. I titled everything. Every deodorant, every hack, EVERYTHING but nothing would work. Then a youtuber I watch recommended in one of her videos to use Certain Dri I bought it and WOW! It’s now the second week and I barely sweat throughout the day. I still get a small little tiny pit but it’ll literally be the size of a dime. It gets smaller and smaller each day. The only thing that SUCKS so bad about this product is the itch. Seconds after I put it on at night I’ll get this unbearable itch that’s so painful. Half of the time doesn’t even allow me to sleep. But I’m the end, it’s worth it.


Oct 29, 2018

Great results, certain dri
I understand the itch many of you are complaining about. I found using baby powder after it is dry or even use with a solid antiperspirant. I had to apply the certain dry daily for about 2 weeks, then it started to work. I then only had to reapply 1 time per week. For the smell issue, use a deodorant. Certain dry does work, I had zero sweat once I used it regularly. Don't stop, I would shave at night, apply in the morning wnd lay on the bed with arms over my head till it drys. Then get dressed.
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